化粧品OEM 小ロットにも対応 株式会社イザヴェル

Bio Placenta is a form of “biological placenta” created through modern biotechnology, in which growth-factor peptides are synthesized using recombinant DNA techniques and microbial fermentation. The goal of this technology is to replicate the natural growth factors found in human placenta in a safe, stable, and animal‑free manner.

1. Scientific Basis of Bio Placenta

The human placenta contains numerous growth factors that regulate cell development. However, using natural placenta poses challenges such as inconsistent composition, contamination risks, and difficulty ensuring purity.

Bio Placenta overcomes these issues by:

  • Synthesizing peptides through microbial biotechnology
  • Standardizing concentrations
  • Ensuring high purity
  • Reproducing biological activity similar to natural placenta

As a result, Bio Placenta can activate:

  • Keratinocyte proliferation
  • Collagen and elastin synthesis
  • Accelerated wound healing
  • Improved microcirculation
  • Reduced oxidative stress

2. Peptide Components in Bio Placenta

2.1. EGF (Epidermal Growth Factor)

EGF plays a key role in:

  • Keratinocyte proliferation
  • Shortening wound‑healing time
  • Strengthening the skin barrier
  • Reducing fine lines

It binds to EGFR receptors and activates the MAPK/ERK pathway to accelerate cell division.

2.2. IGF (Insulin-like Growth Factor)

Acts deeper in the dermis, stimulating fibroblasts.

Main functions:

  • Increases collagen type I & III
  • Boosts hyaluronic acid production
  • Thickens the epidermis
  • Supports connective‑tissue repair

Highly effective for aging or thin skin.

2.3. aFGF (Acidic Fibroblast Growth Factor)

aFGF promotes:

  • Fibroblast proliferation
  • Growth of connective‑tissue cells
  • Faster tissue regeneration
  • Improvement of atrophic scars

Essential for dermal reconstruction.

2.4. PGF (Placental Growth Factor)

A peptide involved in angiogenesis.

Functions:

  • Enhances microcirculation
  • Improves oxygen and nutrient delivery
  • Accelerates wound healing
  • Boosts cellular vitality

Helps skin recover faster and appear brighter.

2.5. TRX (Thioredoxin Peptide)

A strong antioxidant peptide.

Functions:

  • Reduces oxidative stress
  • Protects cellular DNA
  • Decreases inflammation
  • Stabilizes the intracellular environment

Protects skin from UV and pollution damage.

3. Synergistic Mechanism of the 5 Peptides

Together, the peptides create a multi‑layered regenerative system:

  • EGF + IGF: cell proliferation + collagen increase
  • aFGF: connective‑tissue reconstruction
  • PGF: enhanced circulation and nutrient transport
  • TRX: cellular protection and antioxidation

Benefits:

  • Faster recovery after peel/laser/microneedling
  • Reduced redness and inflammation
  • Improved elasticity
  • Reduced wrinkles
  • Brighter, more even skin tone
  • Long‑term structural stability

4. Applications of Bio Placenta in Cosmetics

Suitable for:

  • Recovery serums
  • Post‑treatment ampoules
  • Regenerative creams
  • Intensive repair masks
  • Anti‑aging products

Safe for:

  • Sensitive skin
  • Thin/weak skin
  • Damaged skin
  • Post‑procedure skin

Izavell-OEM Production from 1,000 pcs – For Brands Seeking Distinctive Identity

If you plan to develop:

  • Bio Placenta Serum
  • Intensive Recovery Ampoule
  • Regenerative Cream
  • Bio Placenta Mask

Izavell offers OEM manufacturing from 1,000 pcs, including:

  • Custom formulation based on your concept
  • Packaging, branding, and story development
  • Stability & safety testing
  • Full regulatory documentation
  • Fast production with export‑grade quality

You bring the idea — Izavell turns it into a real product.

Conclusion

Bio Placenta is one of the most advanced biological peptide systems available today. With PGF, aFGF, IGF, EGF, and TRX, it provides comprehensive skin regeneration—from cell proliferation and tissue repair to improved circulation and antioxidant protection.

It is ideal for modern skincare products focused on repair, rejuvenation, and regeneration.